Essentials: The Biology of Slowing & Reversing Aging

October 30, 2025 33m 19 chapters

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Chapters (19)

0:00 David Sinclair 0:20 Longevity, Anti-Aging, Aging as a Disease 2:27 Causes of Aging; Epigenome & Genes 4:53 CD & Scratches Analogy, DNA, Silencing & Expressing Genes 6:44 Physical Appearance & Aging 7:36 Childhood Development & Aging, Horvath Clock, Accelerate Aging 10:13 Rates of Puberty & Aging, Growth Hormone 11:20 Body Size & Longevity; Epigenetics 11:50 Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose 15:14 Tool: Skip a Meal 15:50 Longer Fasts & Autophagy, “Deep Cleanse”; Fluids, Electrolytes 17:28 Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors 21:37 Breaking a Fast, Tools: Do Your Best; Transitions 24:13 Sirtuins, NAD, NMN Supplementation 26:20 Iron & Senescent Cells; Personalize Medicine

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